Dosing for moderate to severe glabellar lines
|Dilution chart for the treatment of moderate to severe glabellar lines1|
|Dilution for 300-U vial||Concentration|
|1.5 mL||10 U/0.05 mL|
|2.5 mL||10 U/0.08 mL|
- Dysport is supplied as a single-use, sterile, 300-U vial, reconstituted with sterile, preservative-free, 0.9% sodium chloride solution. Do not use Dysport after the expiration date on the vial.1
- Dysport contains a unique hologram on the carton. If you do not see the hologram, do not use the product. Instead, contact 855-463-5127.
Important information about the Dysport® injection process.
Before injecting and treating patients with Dysport, take note of the location, size, and use of muscles.1
- Have patient frown while you palpate the tensed muscle mass. Physicians administering Dysport must understand the relevant neuromuscular and/or orbital anatomy of the area involved and any alterations to the anatomy due to prior surgical procedures.
- Identify the lateral corrugator and vertical procerus muscles. The corrugator depresses the skin, creating a "furrowed" vertical line surrounded by tensed muscle.
- Inject Dysport by advancing a 30-gauge needle through the skin into the underlying muscle while applying finger pressure on the superior medial orbital rim.
- Inject a total of 50 U of Dysport in 5 equally divided aliquots of 10 U into each of 5 sites, 2 in each corrugator muscle, and 1 in the procerus muscle.
Note: Location, size, and use of muscles vary markedly among individuals.
Important safety information about ptosis*
- Carefully examine the upper lid for separation or weakness of the levator palpebrae muscle (true ptosis), evaluate lash ptosis, and identify range of lid excursion while manually depressing the frontalis to assess compensation.
- Avoid injecting near the levator palpebrae superioris, particularly in patients with larger brow depressor complexes.
- Inject into the medial corrugator at least 1 cm above the bony supraorbital ridge.
- Ensure the injected volume/dose is accurate and, where feasible, kept to a minimum.
- Do not inject Dysport closer than 1 cm above the central eyebrow.
- To avoid increased risk of ptosis, adhere to recommended dosage.
*An abnormally low position or drooping of the upper eyelid
DOSAGE AND ADMINISTRATION: The potency Units of Dysport are specific to the preparation and assay method utilized. They are not interchangeable with other preparations of botulinum toxin products and, therefore, units of biological activity of Dysport cannot be compared to or converted into units of any other botulinum toxin products assessed with any other specific assay method.
- Dysport Prescribing Information. Galderma Laboratories, L.P. Fort Worth, TX. July 2015.